近五年主持承擔的項目：
- 1. 國家自然科學基金聯合基金重點項目，“基于中藥化學尊龍凱時 - 人生就是搏!學的山東道地藥材酸棗仁與遠志安神功效現代科學闡釋研究”（U23A20514），2024.1-2027.12，經費119萬元，子課題負責人。
- 2. ”國家重點研發計劃課題，“基于尊龍凱時 - 人生就是搏!效應和DNA 身份證的中成藥質量控制技術研究及其應用”（2018YFC1707303），2018.12-2021.12，經費205萬元，負責人。
- 3. 國家自然科學基金聯合基金重點項目，“基于斑馬魚模型的西沙群島海綿共生體抗炎活性先到化合物的發現與優化”（U2006204），2021.1-2024.12，284萬元，子課題負責人。
- 4. 國家海洋公益性行業科研專項，“海產多不飽和脂肪酸磷脂規模化制備技術的研究及產業化示范”（201505030-2），2015.01~2018.12，經費235萬元，負責人。
- 5. 山東省自然科學基金重大基礎研究項目，“針對重大疾病的深海微尊龍凱時 - 人生就是搏!藥用活性分子的高效發現與作用機制研究”（ZR2021ZD29），2021.01-2024.12，經費200萬，負責人。
- 6. 山東重大科技創新工程專項，中藥制造全過程質量控制關鍵技術及中藥智能制造產業化示范(2022CXGC020515)，2022.12-2025.12，經費190萬元，子課題負責人。
- 7. 山東省重點研發計劃項目（醫用食品專項），“用于孕期營養補充的固態特醫食品制備關鍵技術及產品研發”（2017YYSP032），2017-2019，經費80萬，負責人。
- 8. 濟南市20條扶持項目-科研帶頭人工作室“基于斑馬魚模型的藥物活性篩選關鍵技術研究與應用”，2021.01-2023.12，經費50萬，項目負責人
近三年代表性論文（第一或通訊作者）：
- Zhang Y, Xia Q, Wang J, Zhuang K, Jin H*, Liu K*. Progress in using zebrafish as a toxicological model for traditional Chinese medicine. J Ethnopharmacol. 2022, 282:114638
- Dongjie S, Rajendran RS, Xia Q, She G, Tu P, Zhang Y*, Liu K*. Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model. Biomed Pharmacother. 2022, 148:112706
- Zhu Y, Li P, Meng R, Li X*, Qiu Y, Wang L, Zhang S, Zhang X, Lin H, Zhai H, Liu K*. Lipid Profiles of the Heads of Four Shrimp Species by UPLC-Q-Exactive Orbitrap/MS and Their Cardiovascular Activities. Molecules. 2022, 27(2):350
- Jin M#, Li N#, Sheng W, Ji X, Liang X, Kong B, Yin P, Li Y, Zhang X, Liu K*. Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods. Environ Int, 2021, 146, 106179
- Yang X, Wang X, Gao D, Zhang Y, Chen X, Xia Q, Jin M, Sun C, He Q, Wang R*, Liu K*. Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways. Toxicol Lett, 2021, 350: 71-80
- Li P, Zhang M, Li H, Wang R, Hou H, Li X, Liu K*, Chen H*. New prenylated indole homodimeric and pteridine alkaloids from the marine-derived fungus Aspergillus austroafricanus Y32-2. Mar Drugs, 2021, 19: 98
- Li P, Zhang M, Xie D, Zhang X, Zhang S, Gao F, Wang Y, Hsiao CD, Li X*, Liu K*. Characterization and bioactivities of phospholipids from squid viscera and gonads using ultra-performance liquid chromatography-Q-exactive orbitrap/mass spectrometry-based lipidomics and zebrafish models. Food Funct, 2021, 12: 7986-7996
- Zhang M, Li P, Wang F, Zhang S, Li H, Zhang Y, Wang X, Liu K*, Li X*. Separation, identification and cardiovascular activities of phospholipid classes from the head of Penaeus vannamei by lipidomics and zebrafish models. Food Funct, 2021, 12: 2282-2291
- Zhang M, Li P, Zhang S, Zhang X, Wang L, Zhang Y, Li X*, Liu K*. Study on the mechanism of the Danggui-Chuanxiong Herb Pair on treating thrombus through network pharmacology and zebrafish models. ACS Omega, 2021, 6: 14677-14691
- Ren Q, Gao D, Mou L, Zhang S, Zhang M, Li N, Sik A, Jin M*, Liu K*. Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. Eur J Pharmacol, 2021, 912: 174589
- Sheng W*, Weng S, Li F, Zhang Y, He Q, Sheng W, Fu Y, Yan H, Liu K*. Immunohistological localization of Mel1a aelatonin receptor in pigeon retina. Nat Sci Sleep, 2021, 13: 113-121.
- Jin M, Dang J, Paudel YN, Wang X, Wang B, Wang L, Li P, Sun C, Liu K*. The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. Sci Total Environ, 2021, 776: 145963
- Zhang X, Li H, Wang L, Zhang S, Wang F, Lin H, Gao S, Li X*, Liu K*. Anti-inflammatory peptides and metabolomics-driven biomarkers discovery from sea cucumber protein hydrolysates. J Food Sci, 2021, 86: 3540-3549
- Sun M, Liu Q, Liang Q, Gao S, Zhuang K, Zhang Y, Zhang H, Liu K*, She G*, Xia Q*. Toosendanin triggered hepatotoxicity in zebrafish via inflammation, autophagy, and apoptosis pathways. Comp Biochem Physiol C Toxicol Pharmacol, 2021, 250:109171
- Xia Q, Gao S, Rapael Gnanamuthu SR, Zhuang K, Song Z, Zhang Y, Wang X, Tu P, Li J*, Liu K*. Involvement of Nrf2-HO-1/JNK-Erk signaling pathways in aconitine-induced developmental toxicity, oxidative stress, and ROS-mitochondrial apoptosis in zebrafish embryos. Front Pharmacol, 2021, 12:642480
- Liu L, Wu F, Zhu C, Zou H, Kong R, Ma Y, Su D, Song G, Zhang Y*, Liu K*. Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish. Chemosphere, 2021, 265: 129109
- Maharajan K, Xia Q, Duan X, Tu P, Zhang Y*, Liu K*. Therapeutic importance of Zishen Yutai Pill on the female reproductive health: a review. J Ethnopharmacol, 2021, 281: 114523
- Sheng W , Wang K , Gao N , Wang L , Wang R , Zhang X , Chen X , Zhang Y , Zhu B*, Liu K*. A novel p-dimethylaminophenylether-based fluorescent probe for the detection of native ONOO− in cells and zebrafish. Analyst, 2021, 146: 5264
- Zhang X, Han L, Li P, Zhang S, Zhang M, Li X, Chu J, Wang L, Tu P, Zhang Y*, Liu K*. Region-specific biomarkers and their mechanisms in the treatment of lung adenocarcinoma: a study of Panax quinquefolius from Wendeng, China. Molecules, 2021, 26: 6829
- Sheng W, Yu Y, Gao N, Jin M, Wang L, Li N, Li C, Zhang H, Zhang Y, Liu K*. An ultrasensitive ratiometric fluorescent probe for the detection of Hg2+ and its application in cell and zebrafish. Anal Methods, 2021, 13: 1043
- Gao Y, Zhang S, Wan J, Wang R, Liu K*. A novel active peptide from Rapana venosa protects against gentamicin-induced sensory hair cell loss in zebrafish. Int J Pept Res Ther, 2021, 27:641–649.
- Jin, M., Zhang, B., Sun, Y., Zhang, S., Li, X., Sik, A., Bai, Y., Zheng, X., Liu K.*. Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish, Neuropharmacology, 2020, 162, 107-760.
- Jin, M., Gao, D., Wang, R., Sik, A., Liu K.* Possible involvement of TGF-β-SMAD-mediated epithelial mesenchymal transition in pro metastatic property of PAX6. Oncol Rep, 2020, 44(2), 555-564.
- Li, X., Li, C. , Zhu, Y., Shi, Y., Zhang, X., Zhang, S., Wang, L., Lin, H., Hou, H., Hsiao, C., Han, L.*, Liu K*.Lipid fingerprinting of different material sources by UPLC-Q-Exactive Orbitrap/MS approach and their zebrafish-based activities comparison. J Agric Food Chem, 2020, 68, 2007-2015.
- Liu, L., Wu, F., Zhu, C., Zou, H., Kong, R., Ma, Y., Su, D., Song, G., Zhang, Y.*, Liu K.* Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish. Chemosphere, 2020, 265, 129109
- Manjunatha, B., Han, L., KundapurRajesh, R., Liu K.*, Lee, S*. Herbul black henna (hair dye) causes cardiovascular defects in zebrafish (Danio rerio) embryo model. Environ Sci Pollut Res, 2020, 27, 14150–14159
- Song, Z., Zhang,Y., Zhang, H., Rajendran, R., Wang, R., Hsiao, C., Li, J.*, Xia, Q.*, Liu K.* Isoliquiritigenin triggers developmental toxicity and oxidative stress mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway. Chemosphere, 2020, 246, 125727
- Wang, R., Rostyslav, S., Li, X., Lin, H., Zhang, X., Zhang, S., Liu K.* & Wang, L.* Synthetic and antitumor comparison of 9-O-alkylated and carbohydrate-modified berberine derivatives. J Iran Chem Soc, 2020, 17, 3251-3260
- Wang, L., Yang, X., Li, X., Stoika, R,, Wang, X., Lin, H., Ma, Y., Wang, R*, Liu K.* Synthesis of hydrophobically modified berberine derivatives with high anticancer activity through modulation of the MAPK pathway. New J Chem, 2020, 44, 14024-14034
- Zhang, Y., Wang, C., Jia, Z., Ma, R., Wang, X., Chen, W., Liu K*. Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway. Chem Biol Interact, 2020, 316, 108928.
- 鄒鴻遠，朱成悅，張姍姍，孔銳琦，張云*，劉可春*。牡丹籽油微囊粉對異煙肼誘導的斑馬魚發育毒性的保護作用。山東科學，2021，34（4）：45-51
- 段秀英，馬瑞嬌，張云*，劉可春*。斑馬魚炎癥模型及其在中藥抗炎領域的應用。藥物評價研究。2021，44（8）：1573-1580
- 李風玲，李陳欽瑤，段秀英，盧圣鄂，任風鳴，劉可春*，張云*。三峽陽菊葉水提物的抗炎作用研究。藥物評價研究，2021，44（8）：1600-1666
- 陳錫強，張云，劉可春*。新綠原酸抑制人宮頸癌HeLa細胞遷移的實驗研究。2021，44（8）:1588-1593。
- 王鳳霞，張云，李曉彬，侯海榮，劉可春*。小青龍湯用于新冠肺炎患者救治可行性分析。陜西中醫藥大學學報，2021，44（4）：11-14
- 王鳳霞，張姍姍，張軒銘，王利振，張夢啟，李培海，李曉彬*，劉可春*，邢澍。山東 4 種常見蝦蝦頭品質分析與評價。漁業科學進展，2021，43（2）：228-235
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近三年代表性專利：
- 劉可春，靳夢，等，一種凝血酶原激活因子及含凝血酶原激活因子的快速止血材料，ZL202010434949.8
- 靳夢，劉可春，等，一種蛇毒凝血酶原激活物及基于蛇毒凝血酶原激活物的快速止血材料，ZL202010409822.0
- 王利振，劉可春，等，一種小檗堿亞油酸綴合物及其制備方法和用途，ZL202010223471.4
- 孫晨，劉可春，等，斑馬魚naalad2基因啟動子及其應用，ZL2019107581126
- 陳錫強，劉可春，等，一種鄰二氮雜環化合物在制備抑制TLR4受體的藥物中的用途，ZL 202010591073.8
- 孫晨，張姍姍，劉可春，等，一種活性八肽在保護感覺毛細胞方面的應用，ZL201810915406.0
- 盛文龍，劉可春，等，一種快速高選擇性次溴酸熒光探針、制備方法與應用，發明專利，ZL201911289368.3
- 王雪，劉可春，等，一種斑馬魚老年疾呆模型的建立方法及應用，發明專利，ZL201810724850.4
- 陳錫強，劉可春，等，巖藻多糖組合制劑及其應用，發明專利，ZL201810551255.5
- 張姍姍，劉可春，等，具有修復氧化損傷功能的多肽及其制備方法與應用，發明專利，ZL201810915407.5
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