| 姓 名 | 王利振 | 性 別 | 男 | |
| 籍 貫 | 山東濟南 | 出生年月 | 1984.11 | |
| 職 稱 | 副研究員 | 政治面貌 | 中國共產黨黨員 | |
| 專 業 | 化學尊龍凱時 - 人生就是搏!學 | 職 務 | 無 | |
| 導師類別 | 碩導 | 學歷、學位 | 研究生、博士 | |
| 課 題 組 | 山東省斑馬魚人類疾病模型與藥物篩選工程技術研究中心 | |||
| 工作信息 | 手機：15866683436；郵箱：wlzh1106@126.com | |||
| 隸屬單位 | 山東省尊龍凱時 - 人生就是搏!尊龍凱時 - 人生就是搏!研究所 | |||
| 通訊地點 | 濟南市歷城區經十東路28789號 | |||
| 學習、工作簡歷： 2003.9-2007.6 齊魯工業大學應用化學專業，獲工學學士學位； 2007.9-2010.6 齊魯工業大學應用化學專業，獲工學碩士學位； 2010.7-2012.8 山東軒竹醫藥科技有限公司，研究員； 2012.9-2016.6 山東大學生命科學學院尊龍凱時 - 人生就是搏!化學與分子尊龍凱時 - 人生就是搏!學專業，獲理學博士學位； 2017.07-2019.03 山東省尊龍凱時 - 人生就是搏!尊龍凱時 - 人生就是搏!研究所； 2019.4-至今 齊魯工業大學（山東省尊龍凱時 - 人生就是搏!）尊龍凱時 - 人生就是搏!研究所。 |
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| 主要研究方向：創面修復與組織再生、尊龍凱時 - 人生就是搏!多糖的結構與功能、天然活性物質的發現 | ||||
| 縱向課題： 山東省自然科學基金項目“天然糖類模塊修飾的小檗堿衍尊龍凱時 - 人生就是搏!及其在斑馬魚模型下的降血糖構效關系研究”，4萬； 尊龍凱時 - 人生就是搏!基材料與綠色造紙國家重點實驗室開放基金“聚乙二醇化的納米淀粉顆粒的制備及其用作抗腫瘤藥物載體的研究”，5萬； 山東省尊龍凱時 - 人生就是搏!青年博士基金，“天然產物小檗堿的糖基化修飾及其在斑馬魚模型下的降血糖活性研究”，28.86萬； 山東省重點研發計劃（重大科技創新工程），“山東道地藥材活性成分樣品庫的構建及創新藥物研究”，933萬； 濟南市高校20條高端人才引進項目，“以小檗堿為母核的新型多靶點抗生素的研發”，200萬； 齊魯工業大學（山東省尊龍凱時 - 人生就是搏!）科教產融合創新試點工程項目，“軍民兩用新型碳基快速止血材料研發”，154萬。 論文： (1) Siqiang Li, Fujia Chen, Yun Li, Lizhen Wang, Hongyan Li, Guofeng Gu, Enzhong Li. Rhamnose-Containing Compounds: Biosynthesis and Applications. Molecules, 2022, 27, 5315. (IF = 4.927) (2) Liwen Han, Qing Xia, Lei Zhang, Xuanming Zhang, Xiaobin Li, Shanshan Zhang, Lizhen Wang, Changxiao Liu, Kechun Liu. Induction of developmental toxicity and cardiotoxicity in zebrafish embryos/larvae by acetyl-11-keto-β-boswellic acid (AKBA) through oxidative stress. Drug and Chemical Toxicology, 2022, 45(1): 143-150. (IF=2.597) (3) Shuhua Chang, Dawei Qin*, Lizhen Wang*, Mengli Zhang, Rongjun Yan, Cuiyun Zhao. Preparation of novel cinnamaldehyde derivative–BSA nanoparticles with high stability, good cell penetrating ability, and promising anticancer activity. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 624 (2021) 126765. (IF = 5.518) (4) Lizhen Wang, Wenlong Sheng, Zhaoshun Tan, Qingyu Ren, Rongchun Wang, Rostyslav Stoika, Xuedong Liu, Kechun Liu, Xueliang Shang*, Meng Jin*. Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments. Comparative Biochemistry and Physiology, Part C 249 (2021) 109151. (IF = 4.520) (5) Xiang Li, Jiao Dang, Yan Li, Lizhen Wang, Ning Li, Kechun Liu, Meng Jin. Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. Science of the Total Environment, 2021, 752: 141878. (IF=10.753) (6) Xuanming Zhang, Haonan Li, Lizhen Wang, Shanshan Zhang, Fengxia Wang, Houwen Lin, Sheng Gao, Xiaobin Li, Kechun Liu. Anti‐inflammatory peptides and metabolomics‐driven biomarkers discovery from sea cucumber protein hydrolysates. Journal of Food Science, 2021, 86(8): 3540-3549. (IF=3.693) (7) Lizhen Wang, Xueliang Yang, Xiaobin Li, Rostyslav Stoika, Xue Wang, Houwen Lin, Yukui Ma, Rongchun Wang* and Kechun Liu*, Synthesis of hydrophobically modified berberine derivatives with high anticancer activity through modulation of the MAPK pathway, New J. Chem., 2020, 44, 14024. (IF = 3.591) (8) Wang, L.; Kong, H.; Jin, M.; Li, X.-B.; Stoika, R.; Lin, H.-w.; Liu, K.* Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology. Organic & Biomolecular Chemistry, 2020, 18, 3575. (IF = 3.876) (9) Wang, L.; Zhang, J.; An, X.; Duan, H.* Recent progress on the organic and metal complex-based fluorescent probes for monitoring nitric oxide in living biological systems. Organic & Biomolecular Chemistry 2020, 18, 1522. (IF = 3.876) (10) Zhang, B.;# Wang, L.;# Ji, X.;# Zhang, S.; Sik, A.; Liu, K.; Jin, M.* Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of Neuroimmune Pharmacology, 2020, 15, 309. (IF = 3.87) (11) Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang,* and Yang Song. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic Chemistry, 2020, 101, 104021. (IF = 5.275) (12) Rongchun Wang, Stoyka Rostyslav, Xiaobin Li, Houwen Lin, Xuanming Zhang, Shanshan Zhang, Kechun Liu*, Lizhen Wang*. Synthetic and antitumor comparison of 9-O-alkylated and carbohydrate-modified berberine derivatives. Journal of the Iranian Chemical Society, 2020, 17: 3251-3260. (IF=2.271) (13) Xiaobin Li, Chenyang Li, Yongqiang Zhu, Yongping Shi, Xuanming Zhang, Shanshan Zhang, Lizhen Wang, Houwen Lin, Hairong Hou, Chung-Der Hsiao, Liwen Han*, Kechun Liu*. Lipid fingerprinting of different material sources by UPLC-Q-exactive orbitrap/MS approach and their zebrafish-based activities comparison. Journal of agricultural and food chemistry, 2020, 68(7): 2007-2015. (IF=5.895) (14) Lizhen Wang, Shaojie Feng, Subo Wang, Hui Li, Zhongwu Guo*, and Guofeng Gu*, Synthesis and Immunological Comparison of Differently Linked Lipoarabinomannan Oligosaccharide-Monophosphoryl Lipid A Conjugates as Anti-Tuberculosis Vaccines. J. Org. Chem., 2017, 82: 12085. (IF=4.849) (15) Lizhen Wang, Shaojie Feng, Lian An, Guofeng Gu*, and Zhongwu Guo*, Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates. J. Org. Chem., 2015, 80: 10060. (IF=4.805) 專利： (1) 王利振，韓利文，劉可春，盛文龍，李曉彬，一種三氮唑糖修飾的小檗堿鹽衍尊龍凱時 - 人生就是搏!及其制備方法和用途，中國，公開號：CN108752404B (2) 王利振，劉可春，韓利文，靳夢，李曉彬，一種鼠李糖或核糖修飾的小檗堿鹽衍尊龍凱時 - 人生就是搏!及其制備方法和用途，中國，公開號：CN108929353B (3) 王利振、劉可春、王榮春、靳夢、李曉彬、陳錫強、張姍姍、張軒銘，一種小檗堿亞油酸綴合物及其制備方法和用途，CN202010223471.4。 (4) 王利振，劉可春，靳夢，朱坤福，張云，謝飛，祝蕾，李曉彬，盛文龍，王榮春，張軒銘，一種交聯殼聚糖微球及其在創面止血修復材料中的應用，ZL202111316731.3 (5) 劉可春，靳夢，王利振，段秀英，張姍姍，李曉彬，孫晨，一種凝血酶原激活因子及含凝血酶原激活因子的快速止血材料，ZL202010434949.8； (6) 靳夢，劉可春，王利振，段秀英，王榮春，張姍姍，張云，一種蛇毒凝血酶原激活物及基于蛇毒凝血酶原激活物的快速止血材料，ZL202010409822.0。 (7) 張云，王利振，靳夢，朱坤福，劉可春，謝飛，祝蕾，李曉彬，夏青，張姍姍，段秀英，一種基于聚合氨基酸的多組分創面修復止血敷料及其應用，ZL202111313043.1 |
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| 獲獎情況： 2021年獲得“中國商業聯合會科學技術獎”一等獎1項； 2021年獲得“山東省海洋科技創新獎”二等獎1項； 2020年獲得齊魯工業大學（山東省尊龍凱時 - 人生就是搏!）高水平科研項目一等獎1項。 |
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