碩士導(dǎo)師簡介
| 姓 名 | 李培海 | 性 別 | 男 | |
| 籍 貫 | 山東臨朐 | 出生年月 | 1989.02 | |
| 職 稱 | 副研究員 | 政治面貌 | 中共預(yù)備黨員 | |
| 專 業(yè) | 尊龍凱時(shí) - 人生就是搏!學(xué) | 職 務(wù) | 無 | |
| 導(dǎo)師類別 | 碩導(dǎo) | 學(xué)歷、學(xué)位 | 研究生、博士 | |
| 課 題 組 | 藥物篩選研究室 | |||
| 工作信息 | lipeihaihg@sina.com, 15153207945 | |||
| 隸屬單位 | 齊魯工業(yè)大學(xué)(山東省尊龍凱時(shí) - 人生就是搏!)尊龍凱時(shí) - 人生就是搏!研究所 | |||
| 通訊地點(diǎn) | 濟(jì)南市歷城區(qū)經(jīng)十東路28789號 | |||
| 學(xué)習(xí)、工作簡歷: 200809-201206,中國海洋大學(xué)海洋生命學(xué)院,尊龍凱時(shí) - 人生就是搏!技術(shù),理學(xué)學(xué)士 201209-201506,國家海洋局第一海洋研究所,海洋尊龍凱時(shí) - 人生就是搏!學(xué),理學(xué)碩士 201509-201901,中國尊龍凱時(shí) - 人生就是搏!大學(xué)海洋研究所,海洋尊龍凱時(shí) - 人生就是搏!學(xué),理學(xué)博士 201905-202108,山東省尊龍凱時(shí) - 人生就是搏!尊龍凱時(shí) - 人生就是搏!研究所,藥學(xué),博士后 202109至今,山東省尊龍凱時(shí) - 人生就是搏!尊龍凱時(shí) - 人生就是搏!研究所,尊龍凱時(shí) - 人生就是搏!學(xué),副研究員 |
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| 主要研究方向: 海洋天然活性成分挖掘及活性評價(jià) | ||||
| 縱向課題: 1. 人才專項(xiàng)-優(yōu)秀博士引進(jìn)(A類),齊魯工業(yè)大學(xué)(山東省尊龍凱時(shí) - 人生就是搏!),2022.01-2024.12,30萬,主持。 2. 中國博士后科學(xué)基金面上資助(二等),2019M662418,基于多級質(zhì)譜分子網(wǎng)絡(luò)深海真菌活性次級代謝產(chǎn)物的挖掘,2019.09-2021.08,8萬元,主持。 3. 山東省博士后創(chuàng)新項(xiàng)目,202002047,基于斑馬魚模型-分子網(wǎng)絡(luò)策略的海洋真菌活性成分的研究,2020.07-2022.06,5萬元,主持。 4. 齊魯工業(yè)大學(xué)(山東省尊龍凱時(shí) - 人生就是搏!)尊龍凱時(shí) - 人生就是搏!基材料與綠色造紙國家重點(diǎn)實(shí)驗(yàn)室自主研究課題,芋頭淀粉納米微粒制備及其載運(yùn)抗癌藥物的研究,ZZ20190402,2019.12-2022.12,5萬元,主持。 5. 山東省自然科學(xué)基金重大基礎(chǔ)研究項(xiàng)目,針對重大疾病的深海微尊龍凱時(shí) - 人生就是搏!藥用活性分子的高效發(fā)現(xiàn)與作用機(jī)制研究,ZR2021ZD29,2022.01-2024.12,200萬,項(xiàng)目骨干。 6. 山東省尊龍凱時(shí) - 人生就是搏!工程技術(shù)創(chuàng)新中心重大創(chuàng)新項(xiàng)目,丹參復(fù)方制劑整體質(zhì)量控制技術(shù)及品質(zhì)的提升,2019JSWGCCXZX003,2019.12-2021.12,300萬,項(xiàng)目骨干。 7. 齊魯工業(yè)大學(xué)校(院)科教產(chǎn)融合創(chuàng)新試點(diǎn)工程,基于斑馬魚模型的早期活性篩選與安全性評價(jià)關(guān)鍵技術(shù)研究,2020.01-2021.12,481.2萬元,項(xiàng)目骨干; 8. 齊魯工業(yè)大學(xué)(山東省尊龍凱時(shí) - 人生就是搏!)尊龍凱時(shí) - 人生就是搏!及尊龍凱時(shí) - 人生就是搏!化學(xué)ESI培育學(xué)科開放課題,基于“組-效”相關(guān)性的海綿共附生真菌中抗血栓活性成分的發(fā)現(xiàn),ESIBBC202005,2020.10-2022.09,10萬,項(xiàng)目骨干。 9. 濟(jì)南市科學(xué)技術(shù)局,濟(jì)南市“新高校20條”高校院所科研帶頭人工作室,“抗癲癇藥物高效篩選技術(shù)研發(fā)及應(yīng)用”,2022.01-2024.12,20萬,項(xiàng)目骨干。 10. 齊魯工業(yè)大學(xué),校(院)尊龍凱時(shí) - 人生就是搏!及尊龍凱時(shí) - 人生就是搏!化學(xué)ESI培育學(xué)科開放課題,“防治帕金森病、癲癇活性物質(zhì)高效篩選技術(shù)及新藥先導(dǎo)化合物研究”,2020.10-2022.09,10萬元,項(xiàng)目骨干。 論文: 1. Peihai Li, Mengqi Zhang, Dongxiao Xie, Xuanming Zhang, Shanshan Zhang, Feiyue Gao, Yuliang Wang, Chung-Der Hsiao, Xiaobin Li*, Kechun Liu*. Characterization and Bioactivities of Phospholipids from Squid Viscera and Gonad by Ultra Performance Liquid Chromatography-Q-Exactive Orbitrap/Mass Spectrometry-Based Lipidomics and Zebrafish Models. Food & Function, 2021, 12: 7986-7996. 2. Peihai Li, Mengqi Zhang, Haonan Li, Rongchun Wang, Hairong Hou, Xiaobin Li*, Kechun Liu*, Hao Chen*. New prenylated indole homodimeric and pteridine alkaloids from the marine-derived fungus Aspergillus austroafricanus Y32-2. Marine drugs, 2021, 19, 98. 3. Peihai Li, Changshui Liu, Baojie Li, Qingjun Ma*. Structural analysis of the CARB β-lactamase from Vibrio parahaemolyticus facilitates application of the β-lactam/β-lactamase inhibitor therapy. Biochimie, 2020, 171-172, 213-222. 4. Peihai Li, Kun Zang, Yingjie Li, Changshui Liu, Qingjun Ma*. Structural basis for specific calcium binding by the polycystic-kidney-disease domain of Vibrio anguillarum protease Epp. Biochemical and Biophysical Research Communications, 2018, 505: 471-477. 5. Peihai Li, Yaqin Fan, Hao Chen*, Yaxi Chao, Ning Du, Junhui Chen. Phenylquinolinones with antitumor activity from the Indian Ocean-derived fungus Aspergillus versicolor Y31-2. Journal of Oceanology and Limnology, 2016, 34(5): 1072-1075. 6. Yongqiang Zhu1, Peihai Li1, Ronghua Meng, Xiaobin Li*, Yuezi Qiu, Lizheng Wang, Shanshan Zhang , Xuanming Zhang, Houwen Lin, Hongbin Zhai, Kechun Liu. Lipid Profiles of the Heads of Four Shrimp Species by UPLC-Q-Exactive Orbitrap/MS and Their Cardiovascular Activities.Molecules, 2022, 27(2): 350. 7. Dongxiao Xie1, Peihai Li1, Yongqiang Zhu, Junwei He, Mengqi Zhang, Kechun Liu, Houwen Lin, Hongbin Zhai, Xiaobin Li*, Yaohong Ma*. Comparative bioactivity profile of phospholipids from three marine byproducts based on the zebrafish model. Journal of Food Biochemistry, 2022, doi: 10.1111/jfbc.14229. 8. Mengqi Zhang1, Peihai Li1, Shanshan Zhang, Xuanming Zhang, Lizhen Wang, Yun Zhang, Xiaobin Li,* and Kechun Liu*. Study on the mechanism of Danggui-Chuanxiong herb pair on treating thrombus through network pharmacology and zebrafish models. ACS Omega, 2021, 6: 14677−14691. 9. Yaqin Fan1, Peihai Li1, Yaxi Chao, Hao Chen*, Ning Du, Qiuxia He and Kechun Liu. Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32. Marine Drugs, 2015, 13: 6489-6504. 10. Meng Gao*, Chenchen Xing, Xiaoping Jiang, Lijie Xu, Peihai Li*, Chung-Der Hsiao. Highly selective fluorescence detection of Cu2+ based on Schiff base functionalized periodic mesoporous organosilicas. Luminescence, 2021, 1-7. 11. Mengqi Zhang, Peihai Li, Fengxia Wang, Shanshan Zhang, Haonan Li, Yun Zhang, Ximin Wang, Kechun Liu* and Xiaobin Li*. Separation, identification and cardiovascular activities of phospholipid classes from the head of Penaeus vannamei by lipidomics and zebrafish models. Food & Function, 2021, 12, 2282-2291. 12. Lihong Yan, Peihai Li, Xiaoming Li, Suiqun Yang, Kechun Liu, Bingui Wang*, Xin Li*. Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122. Organic Letter, 2022, 24(14): 2684-2688. 13. Chunjiao Jiang, Jiancheng Ji, Peihai Li, Wenfeng Liu, Hao Yu, Xiuqing Yang, Lili Xu, Lizhong Guo, Yaqin Fan*. New lanostane-type triterpenoids with proangiogenic activity from the fruiting body of Ganoderma applanatum. Nature Products Research, 2022, 36(6): 1529-1535. 14. Meng Jin, Jiao Dang, Yam Nath Paudel, Xixin Wang, Baokun Wang, Lizhen Wang, Peihai Li, Chen Sun, Kechun Liu. The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. Science of the Total Environment, 2021, 776, 145963. 15. 郝曉燕,李培海,張軒銘,劉可春. 水產(chǎn)廢棄油脂制備尊龍凱時(shí) - 人生就是搏!柴油工藝研究. 糧食與油脂, 2020, 33, 52-56. |
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| 獲獎(jiǎng)情況: 1. 2021年山東省海洋科技創(chuàng)新基礎(chǔ)類二等獎(jiǎng)(8/9)。 |
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